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Article

Genetics and aetiology of Pagetic disorders of bone.

Archives of biochemistry and biophysics - 15 May 2008

Helfrich Miep H, Hocking Lynne J

Abstract excerpt

Paget's disease of bone (PDB) is a late-onset disorder characterised by focal areas of increased bone turnover containing enlarged hyperactive osteoclasts. The disease has a strong genetic predisposition and mutations in SQSTM1 have been associated with familial and sporadic disease in up to 40%...

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Source

Identifiers

PMID: 18359282
DOI: 10.1016/j.abb.2008.02.045

Genes

SQSTM1
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18359282-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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