Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poliovirus 2C region functions during encapsidation of viral RNA.

Journal of virology - 1 Nov 1997

Vance L M, Moscufo N, Chow M, Heinz B A

Abstract excerpt

We have been exploring the mechanism of action of 5-(3,4-dichlorophenyl) methylhydantoin (hydantoin), an antiviral drug that inhibits the replication of poliovirus in culture. By varying the time of drug addition to infected cells, we found that the drug acts at a stage which is late in the repli...

Topics

Antiviral Agents
Capsid
Carrier Proteins
Guanidine
HeLa Cells
Humans
Hydantoins
Morphogenesis
Mutation
Poliovirus
RNA, Viral
Viral Nonstructural Proteins
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 9343235
DOI: 10.1128/JVI.71.11.8759-8765.1997
PMCID: PMC192341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9343235-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Poliovirus 2C region functions during encapsidation of viral RNA.PMID 9343235Read ↗

DNA encapsidation as a target for anti-herpesvirus drug therapy.Semantic proximity Read ↗

Genetic studies on the poliovirus 2C protein, an NTPase. A plausible mechanism of guanidine effect on the 2C function and evidence for the importance of 2C oligomerization.Semantic proximity Read ↗

A Single Amino Acid Substitution in Poliovirus Nonstructural Protein 2CATPase Causes Conditional Defects in Encapsidation and Uncoating.Semantic proximity Read ↗

The picornavirus replication inhibitors HBB and guanidine in the echovirus-9 system: the significance of viral protein 2CSemantic proximity Read ↗

A "slide-back" mechanism for the initiation of protein-primed RNA synthesis by the RNA polymerase of poliovirus.Semantic proximity Read ↗

Role of amino acid residue 187 of poliovirus polypeptide 2C in determining the guanidine trait.Semantic proximity Read ↗

New small-molecule inhibitors effectively blocking picornavirus replication.Semantic proximity Read ↗

Inhibition of Viral RNA-Dependent RNA Polymerases by Nucleoside Inhibitors: An Illustration of the Unity and Diversity of MechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.