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Article

Diversified sequences of peptide epitope for same-RNA recognition.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1993

Kim S, Ribas de Pouplana L, Schimmel P

Abstract excerpt

We replaced an essential RNA-binding, 30-amino acid helix-loop in an Escherichia coli tRNA synthetase with an inactive and simplified "generic" sequence having 23 of the 30 amino acids as alanine and serine. Wild-type residues were restored in random combinations to generate a library with a sequence complexity of about 1.9 x 10(7). Active molecules were obtained by genetic selection at a frequency of...

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Identifiers

PMID: 7694278
DOI: 10.1073/pnas.90.21.10046
PMCID: PMC47710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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