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Mitochondrial Dynamics and Bioenergetics in iPSC-Derived Neurons with Familial Alzheimer’s Disease Mutations

2024-06-28

Abstract excerpt

<h4>Summary</h4> Mitochondrial (MT) dysfunction is a hallmark of Alzheimer’s Disease (AD), but the specific defects across forms of AD are unknown. We measured multiple parameters of MT dynamics and function, and neurite degeneration, in iPSC-derived human neurons possessing natural and engineered mutations in PS1, PS2, and APP genes. Mutations in all three genes altered MT function measured by basal, ATP-linked,...

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Literature Corpus work: 8d64d90d-f4e9-5f9b-b123-0e75f8e48a0a
DOI: 10.1101/2024.06.24.600414

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