Article
Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein.
Genomics - 1 Oct 1997
Kammerer S, Arnold N, Gutensohn W, Mewes H W, Kunau W H, Höfler G, Roscher A A, Braun A
Abstract excerpt
A protein modification essential for the cellular sorting of many biologically relevant proteins is the covalent attachment of prenyl lipids by specific transferases. Isoprenylation is known to render protein domains hydrophobic, thereby facilitating the interaction with lipid bilayers and/or membrane proteins. The target for the modification with farnesyl groups is the COOH-terminal sequence CaaX. Among the...
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