Evaluating the energetics of empty cavities and internal mutations in proteins.

doi:10.1002/pro.5560061009

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Article

Evaluating the energetics of empty cavities and internal mutations in proteins.

Protein science : a publication of the Protein Society - 1 Oct 1997

Rashin A A, Rashin B H, Rashin A, Abagyan R

Abstract excerpt

The energetics of cavity formation in proteins is evaluated with two different approaches and results are analyzed and compared to experimental data. In the first approach, free energy of cavity formation is extracted by RMS fitting from the distribution of numbers of cavities, N, with different...

Topics

Bacteriophage T4
Calorimetry
Chemical Phenomena
Chemistry, Physical
Crystallography, X-Ray
Enzyme Stability
Hydrogen Bonding
Muramidase
Mutation
Protein Folding
Proteins
Thermodynamics

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