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Article

Prediction of stability changes upon mutation in an icosahedral capsid.

Proteins - 1 Sept 2015

Hickman Samuel J, Ross James F, Paci Emanuele

Abstract excerpt

Identifying the contributions to thermodynamic stability of capsids is of fundamental and practical importance. Here we use simulation to assess how mutations affect the stability of lumazine synthase from the hyperthermophile Aquifex aeolicus, a T = 1 icosahedral capsid; in the simulations the icosahedral symmetry of the capsid is preserved by simulating a single pentamer and imposing crystal symmetry, in effect...

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Identifiers

PMID: 26178267
DOI: 10.1002/prot.24859
PMCID: PMC4737204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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