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Article

Structure-based statistical thermodynamic analysis of T4 lysozyme mutants: structural mapping of cooperative interactions.

Biophysical chemistry - 28 Feb 1997

Hilser V J, Townsend B D, Freire E

Abstract excerpt

The recent development of a structural parameterization of the energetics of protein folding has permitted the incorporation of the functions that describe the enthalpy, entropy and heat capacity changes, i.e. the individual components of the Gibbs energy, into a statistical thermodynamic formalism that describes the distribution of conformational states under equilibrium conditions. The goal of this approach is...

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PMID: 9127939
DOI: 10.1016/s0301-4622(96)02220-x

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