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Article

Adaptation to the fitness costs of antibiotic resistance in Escherichia coli.

Proceedings. Biological sciences - 22 Sept 1997

Schrag S J, Perrot V, Levin B R

Abstract excerpt

Policies aimed at alleviating the growing problem of drug-resistant pathogens by restricting antimicrobial usage implicitly assume that resistance reduces the Darwinian fitness of pathogens in the absence of drugs. While fitness costs have been demonstrated for bacteria and viruses resistant to some chemotherapeutic agents, these costs are anticipated to decline during subsequent evolution. This has recently been...

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Identifiers

PMID: 9332013
DOI: 10.1098/rspb.1997.0178
PMCID: PMC1688596

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