Article
Interactions of HLA-B*4801 with peptide and CD8.
Tissue antigens - 1 Sept 1997
Martinez-Naves E, Barber L D, Madrigal J A, Vullo C M, Clayberger C, Lyu S C, Williams R C, Gorodezky C, Markow T, Petzl-Erler M L, Parham P
Abstract excerpt
Functional properties of the B*4801 allotype were investigated using HLA class I-deficient 221 cells transfected with B*4801 cDNA. From pool sequence analysis of endogenously bound peptides, B*4801 was shown to select for nonamer peptides having glutamine or lysine at position 2 and leucine at the carboxyl-terminus. In an in vitro cell-cell binding assay, B*4801 binds CD8 alpha homodimers weakly due to the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
