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Article

Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus.

Endocrine journal - 1 Oct 2004

Miyako Kenichi, Kohno Hitoshi, Ihara Kenji, Kuromaru Ryuichi, Matsuura Nobuo, Hara Toshiro

Abstract excerpt

Reactive oxygen species are considered to play a role in the development of diabetes mellitus and its complications. Human MTH1 (mutT homologue 1) has 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity, which repairs oxidized forms of dGTP. This enzyme is known to have a thermolabile Met83 variant. We examined whether Val83Met polymorphism of human MTH1 gene is associated with type 1 diabetes mellitus. We...

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Identifiers

PMID: 15516784
DOI: 10.1507/endocrj.51.493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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