Article
Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac.
Immunity - 1 Sept 1997
Yoder M C, Hiatt K, Dutt P, Mukherjee P, Bodine D M, Orlic D
Abstract excerpt
The site of origin of lymphohematopoietic stem cells (HSC) that initiate definitive blood cell production in the murine fetal liver is controversial. Contrary to reports that the preliver yolk sac does not contain definitive HSC, we observed that CD34+ day 9 yolk sac cells repopulated multiple bl...
Topics
- Animals
- Antigens, CD34
- Female
- Fetus
- Growth Substances
- Hematopoietic Stem Cells
- Liver
- Mice
- Phenotype
- Pregnancy
- Proto-Oncogene Proteins c-kit
- RNA, Messenger
- Rats
- Transcription Factors
- Yolk Sac