Article
Imbalanced distribution of Plasmodium falciparum MSP-1 genotypes related to sickle-cell trait.
Molecular medicine (Cambridge, Mass.) - 1 Sept 1997
Ntoumi F, Rogier C, Dieye A, Trape J F, Millet P, Mercereau-Puijalon O
Abstract excerpt
BACKGROUND: The sickle-cell trait protects against severe Plasmodium falciparum malaria and reduces susceptibility to mild malaria but does not prevent infection. The exact mechanism of this protection remains unclear. We have hypothesized that AS individuals are protected by virtue of being less susceptible to a subset of parasite strains; thus we compared some genetic characteristics of parasites infecting AS...
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