Dynamics of Plasmodium falciparum alleles in children with normal haemoglobin and with sickle cell trait in western Uganda.

doi:10.1016/j.trstmh.2008.07.023

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Article

Dynamics of Plasmodium falciparum alleles in children with normal haemoglobin and with sickle cell trait in western Uganda.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jan 2009

Kiwanuka Gertrude N, Joshi Hema, Isharaza William K, Eschrich Klaus

Abstract excerpt

We describe the diversity of Plasmodium falciparum populations in western Uganda and assess the role that asymptomatic malaria carriers with sickle cell trait (HbAS) may be playing on the Plasmodium population structure. We genotyped P. falciparum in 291 samples using merozoite surface protein (MSP) 1 and 2 loci. Extensive genetic diversity was detected among symptomatic children in Mbarara (20 MSP1 alleles; 31...

Topics

Adolescent
Alleles
Animals
Child
Child, Preschool
DNA, Protozoan
Female
Genotype
Humans
Infant
Malaria, Falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Plasmodium falciparum

Polymerase Chain Reaction

Polymorphism, Genetic

Sickle Cell Trait

Uganda

Source

Open in PubMed

Identifiers

PMID: 18789462
DOI: 10.1016/j.trstmh.2008.07.023

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