Article
P53 mutations in tumours induced by intraperitoneal injection of crocidolite asbestos and benzo[a]pyrene in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Aug 1997
Unfried K, Kociok N, Roller M, Friemann J, Pott F, Dehnen W
Abstract excerpt
Mutation analysis of the tumour suppressor gene p53 in tumours induced in the peritoneal cavity of rats revealed differences in the mutational pattern with regard to the carcinogenic substances applied. In tumours induced by benzo[a]pyrene a considerable amount of p53 mutations resulting in an altered protein structure could be detected. For the development of these tumours an escape from the p53 mediated cell...
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