Article
Trp64Arg mutation of beta 3-adrenergic receptor and insulin sensitivity in subjects with glucose intolerance.
Internal medicine (Tokyo, Japan) - 1 Sept 1997
Arii K, Suehiro T, Yamamoto M, Ito H, Ikeda Y, Nakauchi Y, Hashimoto K
Abstract excerpt
We investigated the relationship between the Trp64Arg mutation in the beta 3-adrenergic receptor gene and insulin sensitivity, which was evaluated by the euglycemic-hyperinsulinemic-clamp technique, in 54 patients with impaired glucose tolerance (IGT) or non-insulin dependent diabetes mellitus (NIDDM) who were not receiving insulin therapy. The frequencies of Trp/Trp, Trp/Arg, and Arg/Arg genotypes in the...
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