The significance of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects.

doi:10.1016/s0026-0495(98)90059-2

Article

The significance of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects.

Metabolism: clinical and experimental - 1 Apr 1998

Azuma N, Yoshimasa Y, Nishimura H, Yamamoto Y, Masuzaki H, Suga J, Shigemoto M, Matsuoka N, Tanaka T, Satoh N, Igaki T, Miyamoto Y, Itoh H, Yoshimasa T, Hosoda K, Nishi S, Nakao K

Abstract excerpt

It has been reported that the Trp 64 Arg mutation of the human beta3-adrenergic receptor (beta3-AR) gene is related to an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and features of insulin resistance and weight gain in morbidly obese patients. However, such findings h...

Topics

Adult
Amino Acid Substitution
Arginine
Blood Pressure
Body Mass Index
Case-Control Studies
Diabetes Mellitus, Type 2
Female
Genotype
Glucose Intolerance

Humans

Insulin Resistance

Japan

Lipids

Male

Middle Aged

Point Mutation

Receptors, Adrenergic, beta

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