Cholesterol is required in the exit pathway of Semliki Forest virus.

doi:10.1083/jcb.123.1.57

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Article

Cholesterol is required in the exit pathway of Semliki Forest virus.

The Journal of cell biology - 1 Oct 1993

Marquardt M T, Phalen T, Kielian M

Abstract excerpt

The enveloped alphavirus Semliki Forest virus (SFV) infects cells via a membrane fusion reaction triggered by low pH. For fusion to occur cholesterol is required in the target membrane, as demonstrated both in in vitro fusion assays and in vivo for virus infection of a host cell. In this paper we...

Topics

Aedes
Animals
Cells, Cultured
Cholesterol
Cricetinae
Membrane Fusion
Mutation
Semliki forest virus
Transfection
Vesicular stomatitis Indiana virus
Viral Envelope Proteins
Virus Replication

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