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Article

Cholesterol is required in the exit pathway of Semliki Forest virus.

The Journal of cell biology - 1 Oct 1993

Marquardt M T, Phalen T, Kielian M

Abstract excerpt

The enveloped alphavirus Semliki Forest virus (SFV) infects cells via a membrane fusion reaction triggered by low pH. For fusion to occur cholesterol is required in the target membrane, as demonstrated both in in vitro fusion assays and in vivo for virus infection of a host cell. In this paper we examine the role of cholesterol in postfusion events in the SFV life cycle. Cholesterol-depleted insect cells were...

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Identifiers

PMID: 8408205
DOI: 10.1083/jcb.123.1.57
PMCID: PMC2119816

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Fusion function of the Semliki Forest virus spike is activated by proteolytic cleavage of the envelope glycoprotein precursor p62.Semantic proximity Read ↗

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