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Article

Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle

1 Oct 1997

Abstract excerpt

The study of human papillomavirus type 16 (HPV-16) replication has been impaired because of the lack of a cell culture system that stably maintains viral replication. Recently, cervical epithelial cell populations that stably maintain HPV-16 replicons at a copy number of approximately 1,000 per cell were derived from an HPV-16-infected patient (W12 cell clone 20863 [W12-E cells]). We used neutral/neutral and...

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PMID: 9311789
DOI: 10.1128/jvi.71.10.7167-7179.1997

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