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Propagation of infectious human papillomavirus type 16 by using an adenovirus and Cre/LoxP mechanism

9 Feb 2004

Abstract excerpt

Human papillomavirus type 16 (HPV16) infection is a major risk factor for the development of squamous cell cancers of the cervix and of the head and neck. A major barrier to understanding the progression from initial infection to cancer has been the lack of in vitro models that allow infection, replication, and persistence of the viral genome as an episome in differentiated epithelial cells. To overcome this...

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PMID: 14769917
DOI: 10.1073/pnas.0308615100

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