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Article

Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells

1 May 1995

Abstract excerpt

Integration of human papillomavirus type 16 (HPV-16) DNA into a host chromosome has been hypothesized to result in altered expression of two viral transforming genes, E6 and E7, in cervical cancers. In order to investigate the role that changes in viral genomic state and gene expression play in cervical carcinogenesis, we have derived clonal populations of human cervical epithelial cells which harbor multiple...

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PMID: 7707525
DOI: 10.1128/jvi.69.5.2989-2997.1995

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Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cellsPMID 7707525Read ↗

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