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Article

Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives.

American journal of human genetics - 1 Aug 1997

Rohde K, Teare M D, Santibáñez Koref M

Abstract excerpt

Recently, data on loss of constitutional heterozygosity (LOH) have been used by several groups to increase the power to detect linkage in pedigrees with an inherited cancer predisposition. This approach assumes that the predisposition is due to the inheritance of the defective copy of a tumor suppressor. In order to assess the gain of power expected from the inclusion of LOH data, we simulated segregation and...

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Identifiers

PMID: 9311747
DOI: 10.1086/514849
PMCID: PMC1715901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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