Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives.

doi:10.1086/514849

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Article

Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives.

American journal of human genetics - 1 Aug 1997

Rohde K, Teare M D, Santibáñez Koref M

Abstract excerpt

Recently, data on loss of constitutional heterozygosity (LOH) have been used by several groups to increase the power to detect linkage in pedigrees with an inherited cancer predisposition. This approach assumes that the predisposition is due to the inheritance of the defective copy of a tumor sup...

Topics

Alleles
Breast Neoplasms
Family Health
Female
Gene Deletion
Genes, BRCA1
Genetic Linkage
Genetic Predisposition to Disease
Heterozygote
Humans
Male
Neoplasms
Pedigree

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