The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.

doi:10.1136/jmg.31.6.448

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Article

The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.

Journal of medical genetics - 1 Jun 1994

Teare M D, Rohde K, Santibáñez Koref M F

Abstract excerpt

A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH da...

Topics

Alleles
Breast Neoplasms
Female
Gene Deletion
Genes, Tumor Suppressor
Genes, p53
Genetic Linkage
Heterozygote
Humans
Li-Fraumeni Syndrome
Male
Models, Genetic
Neoplastic Syndromes, Hereditary

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