Abnormal segregation of alleles in CEPH pedigree DNAs arising from allele loss in lymphoblastoid DNA.

doi:10.1006/geno.1993.1019

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Article

Abnormal segregation of alleles in CEPH pedigree DNAs arising from allele loss in lymphoblastoid DNA.

Genomics - 1 Jan 1993

Royle N J, Armour J A, Crosier M, Jeffreys A J

Abstract excerpt

Somatic events that result in the reduction to hemi- or homozygosity at all loci affected by the event have been identified in lymphoblastoid DNA from mothers of two CEPH families. Using suitably informative probes, the allele deficiencies were detected by the abnormal transmission of alleles fro...

Topics

Adult
Alleles
Child
Chromosomes, Human, Pair 19
DNA, Satellite
Female
Gene Deletion
Heterozygote
Homozygote
Humans
Lymphocytes
Male
Pedigree
X Chromosome

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