Article
Using loss of heterozygosity data in affected pedigree member linkage tests.
Genetic epidemiology - 1 Jan 1995
Lustbader E d, Rebbeck T R, Buetow K H
Abstract excerpt
Linkage analysis can be used to test the hypothesis that a marker locus of known location segregates independently from a presumed disease gene. One way to test this hypothesis is to measure the similarity of marker alleles among pairs of relatives affected with the disease. When the disease unde...
Topics
- Alleles
- Biomarkers, Tumor
- Female
- Genes, Recessive
- Genetic Carrier Screening
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Male
- Oncogenes
- Ovum
- Pedigree
- Spermatozoa
- Statistics as Topic