Article
Somatic allele loss in genetic linkage analysis of cancer.
Genetic epidemiology - 1 Jan 1994
Rebbeck T R, Lustbader E D, Buetow K H
Abstract excerpt
The ability to detect or reject genetic linkage in studies of human cancer is often diminished because multiple affected relatives in a pedigree are unavailable for analysis. The observation of somatic allele loss in tumors can provide knowledge about gametic phase. Therefore, consideration of tumor genotype data could be used to obtain knowledge about gametic phase ordinarily gained from a larger sample of...
Topics
- Alleles
- Bias
- Cell Cycle
- Evaluation Studies as Topic
- Genetic Carrier Screening
- Genetic Linkage
- Genotype
- Humans
- Likelihood Functions
- Lod Score
- Models, Genetic
- Neoplasms