Article
DEAF-1 function is essential for the early embryonic development of Drosophila.
Genesis (New York, N.Y. : 2000) - 1 Jun 2002
Veraksa Alexey, Kennison James, McGinnis William
Abstract excerpt
The Drosophila protein DEAF-1 is a sequence-specific DNA binding protein that was isolated as a putative cofactor of the Hox protein Deformed (Dfd). In this study, we analyze the effects of loss or gain of DEAF-1 function on Drosophila development. Maternal/zygotic mutations of DEAF-1 largely result in early embryonic arrest prior to the expression of zygotic segmentation genes, although a few embryos develop...
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