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Article

Rapid Development of Affinity Matured Monoclonal Antibodies Using RIMMS

1 Aug 1997

Abstract excerpt

Affinity matured murine monoclonal antibody producing cell lines can now be rapidly generated using a novel repetitive, multiple site immunization strategy designated RIMMS. RIMMS capitalizes on rapid hypermutation and affinity maturation events which occur in B cell populations localized within secondary lymphatic tissue early in response to antigenic challenges. A murine myeloma cell line, P3XBcl-2-13, stably...

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Identifiers

PMID: 9309429
DOI: 10.1089/hyb.1997.16.381

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