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TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies

21 Feb 2018

Abstract excerpt

EBV infection is associated with a number of malignancies of clinical unmet need, including Hodgkin lymphoma, nasopharyngeal carcinoma, gastric cancer, and posttransplant lymphoproliferative disease (PTLD), all of which express the EBV protein latent membrane protein 2A (LMP2A), an antigen that is difficult to target by conventional antibody approaches. To overcome this, we utilized phage display technology and a...

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PMID: 29467338
DOI: 10.1172/jci.insight.97805

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