Site-specific dissection of substrate recognition by thrombin.

doi:10.1038/nbt0997-891

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Article

Site-specific dissection of substrate recognition by thrombin.

Nature biotechnology - 1 Sept 1997

Vindigni A, Dang Q D, Di Cera E

Abstract excerpt

Current approaches to enzyme specificity focus on the identification of consensus sequences from combinatorial chemistry libraries or phage display. These synthetic substrates can also be used as sensitive probes for the molecular environment of the enzyme specificity sites to determine how they...

Topics

Antithrombins
Bacteriophages
Binding Sites
Drug Design
Fibrinolysin
Mutation
Structure-Activity Relationship
Substrate Specificity
Thermodynamics
Thrombin
Trypsin

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