Article
Identification and characterization of mutations in Ha-Ras that selectively decrease binding to cRaf-1.
The Journal of biological chemistry - 26 Sept 1997
Winkler D G, Johnson J C, Cooper J A, Vojtek A B
Abstract excerpt
The oncoprotein Ras transforms cells by binding to one or more effector proteins. Effector proteins have been identified by their ability to bind to Ras in the GTP but not GDP form, and by their requirement for the Ras effector domain for binding. The best understood Ras effectors are serine/threonine kinases of the Raf family, but other candidate Ras effectors, including a Ral guanine nucleotide dissociation...
Topics
- 3T3 Cells
- Animals
- Binding Sites
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Transformation, Neoplastic
- Enzyme Activation
- GTP-Binding Proteins
- Humans
- Mice
- Mitogen-Activated Protein Kinase 1
- Mutation