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Article

Targeting CRAF kinase in anti-cancer therapy: progress and opportunities.

Molecular cancer - 18 Dec 2023

Wang Penglei, Laster Kyle, Jia Xuechao, Dong Zigang, Liu Kangdong

Abstract excerpt

The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly dysregulated in human malignancies by processes driven by RAS or RAF oncogenes. Among the members of the RAF kinase family, CRAF plays an important role in the RAS-MAPK signaling pathway, as well as in the progression of cancer. Recent research has provided evidence implicating the role of CRAF in the physiological regulation and the...

Topics

Humans
Cell Line, Tumor
Proto-Oncogene Proteins B-raf
MAP Kinase Signaling System
Signal Transduction
Phosphorylation
Mutation
Protein Kinase Inhibitors
Proto-Oncogene Proteins c-raf

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38111008
DOI: 10.1186/s12943-023-01903-x
PMCID: PMC10726672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-38111008-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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