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Article

ProC Global: the first functional screening assay for the complete protein C pathway.

Clinical chemistry - 1 Sept 1997

Dati F, Hafner G, Erbes H, Prellwitz W, Kraus M, Niemann F, Noah M, Wagner C

Abstract excerpt

In clinical practice, venous thromboembolic complications are much more frequent than bleeding disorders. In fact, disturbances within the protein C pathway due to coagulation factor V (FV) Leiden mutation and deficiency of protein C or protein S are the most frequent abnormalities in hereditary thrombophilia. Furthermore, acquired dysfunctions of the protein C system may predispose the single individual to an...

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PMID: 9299966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ProC Global: the first functional screening assay for the complete protein C pathway.PMID 9299966Read ↗

Screening for abnormalities of the protein C anticoagulant pathway using the ProC Global assay. Results of a European multicenter evaluation.Semantic proximity Read ↗

Screening for risk factors for thrombosis using a new generation of assays developed to evaluate the functionality of the protein C anticoagulant pathway.Semantic proximity Read ↗

A modified functional global test to measure protein C, protein S activities and the activated protein C-resistance phenotype.Semantic proximity Read ↗

Modification of the ProC Global assay using dilution of patient plasma in factor V-depleted plasma as a screening assay for factor V Leiden mutation.Semantic proximity Read ↗

Laboratory screening of thrombophilia. Evaluation of the diagnostic efficacy of a global test to detect congenital deficiencies of the protein C anticoagulant pathway.Semantic proximity Read ↗

Genotype-Phenotype Relationships in a Large French Cohort of Subjects with Inherited Protein C Deficiency.Semantic proximity Read ↗

A new chromogenic assay (HemosIL ThromboPath) is sensitive to major prothrombotic risk factors affecting the protein C pathway. Results of a multicenter study.Semantic proximity Read ↗

Tests of global haemostasis and their applications in bleeding disorders.Semantic proximity Read ↗

[National evaluation of the diagnosis of activated protein C resistance].Semantic proximity Read ↗

Activated protein C resistance--a major risk factor for thrombosis.Semantic proximity Read ↗

Phenotyping the haemostatic system by thrombography--potential for the estimation of thrombotic risk.Semantic proximity Read ↗

Hereditary protein C deficiency and thrombosis risk: genotype and phenotype relation in a large Italian family.Semantic proximity Read ↗

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