Article
Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors.
The Journal of clinical investigation - 15 Sept 1997
Cohen O J, Vaccarezza M, Lam G K, Baird B F, Wildt K, Murphy P M, Zimmerman P A, Nutman T B, Fox C H, Hoover S, Adelsberger J, Baseler M, Arthos J, Davey R T, Dewar R L, Metcalf J, Schwartzentruber D J, Orenstein J M, Buchbinder S, Saah A J, Detels R, Phair J, Rinaldo C, Margolick J B, Pantaleo G, Fauci A S
Abstract excerpt
HIV-1-infected long-term nonprogressors are a heterogeneous group of individuals with regard to immunologic and virologic markers of HIV-1 disease. CC chemokine receptor 5 (CCR5) has recently been identified as an important coreceptor for HIV-1 entry into CD4+ T cells. A mutant allele of CCR5 con...
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