Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular analysis of dengue virus attenuation after serial passage in primary dog kidney cells.

The Journal of general virology - 1 Sept 1997

Puri B, Nelson W M, Henchal E A, Hoke C H, Eckels K H, Dubois D R, Porter K R, Hayes C G

Abstract excerpt

The complete nucleotide sequences of the genomes of dengue-1 virus virulent 45AZ5 PDK-O and attenuated vaccine candidate strain 45AZ5 PDK-27 have been determined and compared with the dengue-1 virus Western Pacific (West Pac) 74 parent strain from which 45AZ5 PDK-O was derived. Twenty-five (0.23%...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Genetic Variation
Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney

Share to Molecular Sequence Data

Share to RNA, Viral

Share to Sequence Analysis, DNA

Share to Virulence

Source

Identifiers

PMID: 9292016
DOI: 10.1099/0022-1317-78-9-2287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9292016-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular analysis of dengue virus attenuation after serial passage in primary dog kidney cells.PMID 9292016Read ↗

BIOLOGIC PROPERTIES OF DENGUE VIRUSES FOLLOWING SERIAL PASSAGE IN PRIMARY DOG KIDNEY CELLS: STUDIES AT THE UNIVERSITY OF HAWAIISemantic proximity Read ↗

Dengue type 4 live-attenuated vaccine viruses passaged in vero cells affect genetic stability and dengue-induced hemorrhaging in mice.Semantic proximity Read ↗

Characterizing the molecular basis of attenuation of Marek's disease virus via in vitro serial passage identifies de novo mutations in the helicase-primase subunit gene UL5 and other candidates associated with reduced virulence.Semantic proximity Read ↗

Clustering of mutations within the inverted repeat regions of a serially passaged attenuated gallid herpesvirus type 2 strain.Semantic proximity Read ↗

Accumulation of attenuating mutations in varying proportions within a high passage very virulent plus strain of Gallid herpesvirus type 2.Semantic proximity Read ↗

Replication of the primary dog kidney-53 dengue 2 virus vaccine candidate in Aedes aegypti is modulated by a mutation in the 5' untranslated region and amino acid substitutions in nonstructural proteins 1 and 3.Semantic proximity Read ↗

High genetic stability of dengue virus propagated in MRC-5 cells as compared to the virus propagated in vero cells.Semantic proximity Read ↗

Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53.Semantic proximity Read ↗

Attenuation markers of a candidate dengue type 2 vaccine virus, strain 16681 (PDK-53), are defined by mutations in the 5' noncoding region and nonstructural proteins 1 and 3.Semantic proximity Read ↗

Mutation in the 1D gene (VP1) of Foot-and-mouth disease virus serotype Asia1 during serial cytolytic infections in cell culture.Semantic proximity Read ↗

Dynamic equilibrium of Marek's disease genomes during in vitro serial passage.Semantic proximity Read ↗

Passage of dengue virus type 4 vaccine candidates in fetal rhesus lung cells selects heparin-sensitive variants that result in loss of infectivity and immunogenicity in rhesus macaques.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.