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Article

Dengue type 4 live-attenuated vaccine viruses passaged in vero cells affect genetic stability and dengue-induced hemorrhaging in mice.

PloS one - 1 Jan 2011

Lee Hsiang-Chi, Yen Yu-Ting, Chen Wen-Yu, Wu-Hsieh Betty A, Wu Suh-Chin

Abstract excerpt

Most live-attenuated tetravalent dengue virus vaccines in current clinical trials are produced from Vero cells. In a previous study we demonstrated that an infectious cDNA clone-derived dengue type 4 (DEN-4) virus retains higher genetic stability in MRC-5 cells than in Vero cells. For this study we investigated two DEN-4 viruses: the infectious cDNA clone-derived DEN-4 2A and its derived 3' NCR 30-nucleotide...

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Identifiers

PMID: 22053180
DOI: 10.1371/journal.pone.0025800
PMCID: PMC3203870

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Source receipt: pubmed, retrieved 7 Sept 2026.

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