Article
Replication of the primary dog kidney-53 dengue 2 virus vaccine candidate in Aedes aegypti is modulated by a mutation in the 5' untranslated region and amino acid substitutions in nonstructural proteins 1 and 3.
Vector borne and zoonotic diseases (Larchmont, N.Y.) - 1 Jun 2011
Brault Aaron C, Kinney Richard M, Maharaj Payal D, Green Emily N G, Reisen William K, Huang Claire Y-H
Abstract excerpt
Previous studies have demonstrated reduced replication of the cell culture-adapted Dengue-2 virus (DENV-2) vaccine candidate, primary dog kidney (PDK)-53, compared with the parental DENV-2 strain, 16681, in C6/36 cells. Various DENV-2 mutants incorporating PDK-53 substitutions singly and in combination into the 16681 genetic backbone were used to identify the genetic basis for impaired replication of the vaccine...
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