Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development.

Developmental biology - 1 Sept 1997

Louvi A, Accili D, Efstratiadis A

Abstract excerpt

Genetic analyses of dwarfing phenotypes resulting from targeted mutagenesis of the genes encoding the insulin-like growth factors (IGF-I and IGF-II) and their cognate type 1 IGF receptor (IGF1R) have demonstrated that this signaling system is a major determinant of mouse embryonic growth. Of the two IGF ligands, IGF-I interacts exclusively with IGF1R, whereas IGF-II recognizes an additional receptor (XR), because...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crosses, Genetic
Share to Embryonic and Fetal Development
Share to Insulin-Like Growth Factor II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Pregnancy

Share to Receptor, Insulin

Source

Identifiers

PMID: 9281335
DOI: 10.1006/dbio.1997.8666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development.PMID 9281335Read ↗

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.Semantic proximity Read ↗

Distinct and overlapping functions of insulin and IGF-I receptors.Semantic proximity Read ↗

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).Semantic proximity Read ↗

Knockout of Insulin-Like Growth Factor-1 Receptor Impairs Distal Lung MorphogenesisSemantic proximity Read ↗

IGF-I is required for normal embryonic growth in mice.Semantic proximity Read ↗

Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.Semantic proximity Read ↗

Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds.Semantic proximity Read ↗

Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cellsSemantic proximity Read ↗

Imprinted <i>Grb10</i> , encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor ( <i>Igf1r</i> ) and insulin receptor ( <i>Insr</i> ) genesSemantic proximity Read ↗

Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels.Semantic proximity Read ↗

A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit.Semantic proximity Read ↗

The role of insulin receptor signaling in zebrafish embryogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.