Article
Conditional mutator phenotypes in hMSH2-deficient tumor cell lines.
Science (New York, N.Y.) - 5 Sept 1997
Richards B, Zhang H, Phear G, Meuth M
Abstract excerpt
Two human tumor cell lines that are deficient in the mismatch repair protein hMSH2 show little or no increase in mutation rate relative to that of a mismatch repair-proficient cell line when the cells are maintained in culture conditions allowing rapid growth. However, mutations accumulate at a high rate in these cells when they are maintained at high density. Thus the mutator phenotype of some mismatch...
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