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Article

Mutator phenotypes of common polymorphisms and missense mutations in MSH2.

Current biology : CB - 26 Aug 1999

Drotschmann K, Clark A B, Kunkel T A

Abstract excerpt

Hereditary non-polyposis colorectal cancer (HNPCC) is associated with germline mutations in the DNA mismatch repair gene hMSH2 [1], the human homologue of the Escherichia coli MutS gene. These are mostly nonsense, frameshift or deletion mutations that result in loss of intact protein and complete inactivation of DNA mismatch repair. However, cancer is also associated with hMSH2 missense mutations that are merely...

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Source

Identifiers

PMID: 10469597
DOI: 10.1016/s0960-9822(99)80396-0

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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