Functional analysis of human MutSalpha and MutSbeta complexes in yeast.

doi:10.1093/nar/27.3.736

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Article

Functional analysis of human MutSalpha and MutSbeta complexes in yeast.

Nucleic acids research - 1 Feb 1999

Clark A B, Cook M E, Tran H T, Gordenin D A, Resnick M A, Kunkel T A

Abstract excerpt

Mismatch repair (MMR) is initiated when a heterodimer of hMSH2*hMSH6 or hMSH2*hMSH3 binds to mismatches. Here we perform functional analyses of these human protein complexes in yeast. We use a sensitive genetic system wherein the rate of single-base deletions in a homopolymeric run in the LYS2 ge...

Topics

Alleles
Amino Acid Substitution
Base Pair Mismatch
DNA Repair
DNA-Binding Proteins
Fungal Proteins
Genetic Complementation Test
Heteroduplex Analysis
Humans
Multidrug Resistance-Associated Proteins
MutS Homolog 2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MutS Homolog 3 Protein

Mutation, Missense

Neoplasms

Protein Binding

Proto-Oncogene Proteins

Sequence Homology

Yeasts

Source

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Identifiers

PMID: 9889267
DOI: 10.1093/nar/27.3.736
PMCID: PMC148241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9889267-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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