Article
[Genetic control of metabolism of a mutagenic analog of 6-N-hydroxylaminopurine bases in Saccharomyces cerevisiae yeasts].
Genetika - 1 May 1997
Koz'min S G, Domkin V D, Zekhnov A M, Pavlov Iu I
Abstract excerpt
Yeasts were shown to utilize 6-substituted adenine analogues as a purine source via the reutilization pathway leading to the formation of inosine monophosphate (IMP). This occurs because the ade12 strains with blocked conversion of IMP into adenosine monophosphate (AMP) cannot grow on media containing the above analogues as a sole purine source. Haploid strains with the double mutation ham1 ade2 or ham1 ade5 were...
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