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Article

A critical amino acid residue, asp446, in UDP-glucuronosyltransferase.

The Biochemical journal - 1 Aug 1997

Iwano H, Yokota H, Ohgiya S, Yotumoto N, Yuasa A

Abstract excerpt

An amino acid residue, Asp446, was found to be essential for the enzymic activity of UDP-glucuronosyltransferase (UGT). We obtained a rat phenol UGT (UGT1*06) cDNA (named Ysh) from male rat liver by reverse-transcription (RT)-PCR using pfu polymerase. A mutant Ysh having two different bases, A1337G and G1384A (named Ysh A1337GC1384A), that result in two amino acid substitutions, D446G and V462M, was obtained by...

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PMID: 9271076
DOI: 10.1042/bj3250587
PMCID: PMC1218599

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