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Article

The importance of cysteine 126 in the human liver UDP-glucuronosyltransferase UGT1A6.

Biochimica et biophysica acta - 20 May 2002

Senay Claire, Jedlitschky Gabriele, Terrier Nadège, Burchell Brian, Magdalou Jacques, Fournel-Gigleux Sylvie

Abstract excerpt

The human UDP-glucuronosyltransferase 1A6 (UGT1A6) isoform is actively involved in the detoxication of phenolic compounds. In an effort to gain insight on active-site amino acids, we investigated the functional relevance of cysteinyl residues in the glucuronidation process. The enzyme was irreversibly inactivated upon exposure to thiol-specific reagents, especially N-phenylmaleimide. Site-directed mutagenesis of...

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Identifiers

PMID: 12009407
DOI: 10.1016/s0167-4838(02)00266-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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