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Article

Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism.

Neurology - 1 Aug 1997

Griffiths L R, Nyholt D R, Curtain R P, Goadsby P J, Brimage P J

Abstract excerpt

Migraine shows strong familial aggregation. However, the number of genes involved in the disorder is unknown and not identified. Nitric oxide is involved in the central processing of pain stimuli and plays an important role in the regulation of basal or stimulated vasodilation. Nitric oxide synthase, which controls the synthesis of nitric oxide, could possibly be a cause, or candidate gene, in migraine etiology....

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Source

Identifiers

PMID: 9270610
DOI: 10.1212/wnl.49.2.614

Genes

NOS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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