Assembly of the reovirus outer capsid requires mu 1/sigma 3 interactions which are prevented by misfolded sigma 3 protein in temperature-sensitive mutant tsG453.

doi:10.1016/s0168-1702(96)01372-x

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Article

Assembly of the reovirus outer capsid requires mu 1/sigma 3 interactions which are prevented by misfolded sigma 3 protein in temperature-sensitive mutant tsG453.

Virus research - 1 Dec 1996

Shing M, Coombs K M

Abstract excerpt

A temperature-sensitive reovirus mutant, tsG453, whose defect was mapped to major outer capsid protein sigma 3, makes core particles but fails to assemble the outer capsid around the core at non-permissive temperature. Previous studies that made use of electron cryo-microscopy and image reconstru...

Topics

Capsid
Capsid Proteins
Genes, Viral
Mutation
Protein Conformation
Protein Folding
RNA-Binding Proteins
Reoviridae
Temperature
Viral Proteins
Virus Assembly

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