Article
Familial amyotrophic lateral sclerosis.
Muscle & nerve - 1 Feb 2002
Hand Collette K, Rouleau Guy A
Abstract excerpt
The increasing complexity of the pathways implicated in the pathogenesis of familial amyotrophic lateral sclerosis (ALS) has stimulated intensive research in many directions. Genetic analysis of familial ALS has yielded six loci and one disease gene (SOD1), initially suggesting a role for free radicals in the disease process, although the mechanisms through which the mutant exerts toxicity and results in...
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