Article
Genetics of familial Amyotrophic lateral sclerosis.
Archives italiennes de biologie - 1 Mar 2011
Ticozzi Nicola, Tiloca Cinzia, Morelli Claudia, Colombrita Claudia, Poletti Barbara, Doretti Alberto, Maderna Luca, Messina Stefano, Ratti Antonia, Silani Vincenzo
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a late onset, rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. About 10% of all ALS cases are familial (FALS), and constitute a clinically and genetically heterogeneous entity. To date, FALS has been linked to mutations in 10 different genes and to four additional chromosomal loci. Research...
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