Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review.

doi:10.1016/j.jgg.2025.05.008

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Article

Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review.

Journal of genetics and genomics = Yi chuan xue bao - 1 Oct 2025

Yuan Lamei, Yang Yuewen, Guo Yi, Deng Hao

Abstract excerpt

Amyotrophic lateral sclerosis (ALS), one of the most prevalent neurodegenerative disorders, is pathologically characterized by the progressive degeneration of both upper and lower motor neurons, leading to muscle weakness, paralysis, and death within 2-4 years post-diagnosis. ALS is categorized into familial ALS (FALS) and sporadic ALS, with FALS accounting for approximately 10% of ALS cases. As a genetically...

Topics

Amyotrophic Lateral Sclerosis
Humans
Animals
Genetic Predisposition to Disease
Disease Models, Animal

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Open in PubMed

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PMID: 40446958
DOI: 10.1016/j.jgg.2025.05.008

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