Article
Expression of the farnesyltransferase beta-subunit gene in human ovarian carcinoma: correlation to K-ras mutation.
Gynecologic oncology - 1 Aug 1997
Tanimoto H, Mehta K D, Parmley T H, Shigemasa K, Parham G P, Clarke J, O'Brien T J
Abstract excerpt
The ras signaling protein requires a posttranslational modification to localize it to the inner surface of plasma membrane. In this state it can behave as a signal transduction mediator. Farnesyltransferase plays an important role in this posttranslational processing of ras by attaching a farnesyl group to the cysteine of the ras C-terminal tetrapeptide. In this study, we investigated the relationship of K-ras...
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